All page numbers refer to the World of Darkness rulebook.

Mental Merit: Language (●)
Effect: Your character knows an additional language besides his own, one that he can read, write and speak with fluency. If he wishes to convince others that he is a native speaker, however, the Storyteller might call for an Intelligence + Expression roll, contested with a reflexive Intelligence + Academics roll by anyone who is suspicious.
You must specify which language your character is familiar with when purchasing this Merit. You may take this Merit multiple times, with a different language for each.

Disease, Drugs and Poisons
Resisting these is no longer a contested roll, except in the most severe cases (such as cancer, arsenic, etc.), in which case the Storyteller sets a success threshold. In most cases, however, only a single success on a Resolve + Stamina roll, modified by [severity/potency/toxicity], is needed to resist. (Pgs. 176-177, & 180-181.)

Ephemeral Nomenclature
The WW boys made some organizational changes to ghosts and "spirits." These don't affect how ghosts function right now, but they'll come to mean more going forward into Werewolf and Mage. A ghost is no longer a "spirit" in the context of the rules. A ghost is an entity that is made of spiritual stuff, but it is distinct from a "spirit." A spirit is a creature made of Essence, with an origin specifically in the Shadow Realm. The collective description for spiritual creatures (both spirits and ghosts) is "ephemera," though the two branches of ephemera (spirits and ghosts) are separate types of entities. You can't bind a ghost into a fetish, for example, and werewolf powers don't typically affect or relate to ghosts. (Pgs. 208-216.)

Miscellaneous
Damage From Vehicles: If your fool ass gets run over, it's lethal damage, not bashing (pg. 144).
Nerfing Critters: Drop the Resolve ratings for the raven and dog entries from 4 to 3 (pg. 203), and adjust Willpower accordingly.